A set of diseases known as dysproteinemias are defined by an excessive synthesis of a monoclonal (M) protein as a result of aberrant clonal growth of plasma cells. An immunoglobulin fragment (light chain or heavy chain) or a whole immunoglobulin can both be this M protein. These conditions are collectively referred to as "dysproteinemias," "paraproteinemias," or "monoclonal gammopathies" and include multiple myeloma, light-chain amyloidosis, monoclonal gammopathy of uncertain significance, and others.

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